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Lokossou A. G., Dechavanne Célia, Bouraima A., Courtin David, Le Port A., Ladekpo R., Noukpo J., Bonou D., Ahouangninou C., Sabbagh A., Fayomi B., Massougbodji A., Garcia André, Migot Nabias Florence. (2013). Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns. Bmc Infectious Diseases, 13, 215. ISSN 1471-2334

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Lien direct chez l'éditeur doi:10.1186/1471-2334-13-215

Titre
Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000320052800001
AuteursLokossou A. G., Dechavanne Célia, Bouraima A., Courtin David, Le Port A., Ladekpo R., Noukpo J., Bonou D., Ahouangninou C., Sabbagh A., Fayomi B., Massougbodji A., Garcia André, Migot Nabias Florence.
SourceBmc Infectious Diseases, 2013, 13, p. 215. p. 215 ISSN 1471-2334
RésuméBackground: Particular cytokine gene polymorphisms are involved in the regulation of the antibody production. The consequences of already described IL-4, IL-10 and IL-13 gene polymorphisms on biological parameters and antibody levels were investigated among 576 mothers at delivery and their newborns in the context of P. falciparum placental malaria infection. Methods: The study took place in the semi-rural area of Tori-Bossito, in south-west Benin, where malaria is meso-endemic. Six biallelic polymorphisms were determined by quantitative PCR using TaqMan (R) Pre Designed SNP Genotyping Assays, in IL-4 (rs2243250, rs2070874), IL-10 (rs1800896, rs1800871, rs1800872) and IL-13 (rs1800925) genes. Antibody responses directed to P. falciparum MSP-1, MSP-2, MSP-3, GLURP-R0, GLURP-R2 and AMA-1 recombinant proteins were determined by ELISA. Results: The maternal IL-4(-590)*T/IL-4(+33)*T haplotype (one or two copies) was associated with favorable maternal condition at delivery (high haemoglobin levels, absence of placental parasites) and one of its component, the IL-4(-590) TT genotype, was related to low IgG levels to MSP-1, MSP-2/3D7 and MSP-2/FC27. Inversely, the maternal IL-10(-1082) AA was positively associated with P. falciparum placenta infection at delivery. As a consequence, the IL-10(-819)*T allele (in CT and TT genotypes) as well as the IL-10(-1082)*A/IL-10(-819)*T/IL-10(-592)*A haplotype (one or two copies) in which it is included, were related to an increased risk for anaemia in newborns. The maternal IL-10(-1082) AA genotype was related to high IgG levels to MSP-2/3D7 and AMA-1 in mothers and newborns, respectively. The IL-13 gene polymorphism was only involved in the newborn's antibody response to AMA-1. Conclusion: These data revealed that IL-4 and IL-10 maternal gene polymorphisms are likely to play a role in the regulation of biological parameters in pregnant women at delivery (anaemia, P. falciparum placenta infection) and in newborns (anaemia). Moreover, IL-4, IL-10 and IL-13 maternal gene polymorphisms were related to IgG responses to MSP-1, MSP-2/3D7 and MSP-2/FC27 in mothers as well as to AMA-1 in newborns.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050]
LocalisationFonds IRD [F B010060417]
Identifiant IRDfdi:010060417
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010060417

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