@article{fdi:010060390,
  title = {{I}nsecticide resistance alleles affect vector competence of {A}nopheles gambiae s.s. for {P}lasmodium falciparum field isolates},
  author = {{A}lout, {H}. and {T}uikue {N}dam, {N}icaise and {S}andeu, {M}. {M}. and {D}j{\'e}gbe, {I}. and {C}handre, {F}abrice and {D}abir{\'e}, {R}. {K}. and {D}jogb{\'e}nou, {L}. {S}. and {C}orbel, {V}incent and {C}ohuet, {A}nna},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he widespread insecticide resistance raises concerns for vector control implementation and sustainability particularly for the control of the main vector of human malaria, {A}nopheles gambiae sensu stricto. {H}owever, the extent to which insecticide resistance mechanisms interfere with the development of the malignant malaria parasite in its vector and their impact on overall malaria transmission remains unknown. {W}e explore the impact of insecticide resistance on the outcome of {P}lasmodium falciparum infection in its natural vector using three {A}n. gambiae strains sharing a common genetic background, one susceptible to insecticides and two resistant, one homozygous for the ace-1({R}) mutation and one for the kdr mutation. {E}xperimental infections of the three strains were conducted in parallel with field isolates of {P}. falciparum from {B}urkina {F}aso ({W}est {A}frica) by direct membrane feeding assays. {B}oth insecticide resistant mutations influence the outcome of malaria infection by increasing the prevalence of infection. {I}n contrast, the kdr resistant allele is associated with reduced parasite burden in infected individuals at the oocyst stage, when compared to the susceptible strain, while the ace-1({R}) resistant allele showing no such association. {T}hus insecticide resistance, which is particularly problematic for malaria control efforts, impacts vector competence towards {P}. falciparum and probably parasite transmission through increased sporozoite prevalence in kdr resistant mosquitoes. {T}hese results are of great concern for the epidemiology of malaria considering the widespread pyrethroid resistance currently observed in {S}ub-{S}aharan {A}frica and the efforts deployed to control the disease.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {5},
  pages = {e63849},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0063849},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060390},
}