@article{fdi:010060382,
  title = {{M}ortality, {AIDS}-morbidity, and loss to follow-up by current {CD}4 cell count among {HIV}-1-infected adults receiving antiretroviral therapy in {A}frica and {A}sia : data from the {ANRS} 12222 collaboration},
  author = {{G}abillard, {D}. and {L}ewden, {C}. and {N}doye, {I}. and {M}oh, {R}. and {S}egeral, {O}. and {T}onwe-{G}old, {B}. and {E}tard, {J}ean-{F}ran{\c{c}}ois and {P}agnaroat, {M}. and {F}ournier-{N}icolle, {I}. and {E}holie, {S}. and {K}onate, {I}. and {M}inga, {A}. and {M}poudi-{N}gole, {E}. and {K}oulla-{S}hiro, {S}. and {Z}annou, {D}. {M}. and {A}nglaret, {X}. and {L}aurent, {C}hristian},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n resource-limited countries, estimating {CD}4-specific incidence rates of mortality and morbidity among patients receiving antiretroviral therapy ({ART}) may help assess the effectiveness of care and treatment programmes, identify program weaknesses, and inform decisions. {M}ethods: {W}e pooled data from 13 research cohorts in 5 sub-{S}aharan {A}frican ({B}enin, {B}urkina {F}aso, {C}ameroon, {C}ote d'{I}voire, and {S}enegal) and 2 {A}sian ({C}ambodia and {L}aos) countries. {HIV}-infected adults (18 years and older) who received {ART} in 1998-2008 and had at least one {CD}4 count available were eligible. {C}hanges in {CD}4 counts over time were estimated by a linear mixed regression. {CD}4-specific incidence rates were estimated as the number of first events occurring in a given {CD}4 stratum divided by the time spent within the stratum. {R}esults: {O}verall 3917 adults (62% women) on {ART} were followed up during 10,154 person-years. {I}n the <= 50, 51-100, 101-200, 201-350, 351-500, 501-650, and.650 cells/mm(3) {CD}4 cells strata, death rates were 20.6, 11.8, 6.7, 3.3, 1.8, 0.9, and 0.3 per 100 person-years; {AIDS} rates were 50.5, 32.9, 11.5, 4.8, 2.8, 2.2, and 2.2 per 100 person-years; and loss-to-follow-up rates were 4.9, 6.1, 3.5, 3.1, 2.9, 1.7, and 1.2 per 100 person-years, respectively. {M}ortality and morbidity were higher during the first year after {ART} initiation. {C}onclusions: {I}n these resource-limited settings, death and {AIDS} rates remained substantial after {ART} initiation, even in individuals with high {CD}4 cell counts. {E}nsuring earlier {ART} initiation and optimizing case finding and treatment for {AIDS}-defining diseases should be seen as priorities.},
  keywords = {adults ; morbidity ; mortality ; {CD}4 ; {HIV} ; {A}frica ; antiretroviral ; {AFRIQUE} ; {ASIE}},
  booktitle = {},
  journal = {{J}aids.{J}ournal of {A}cquired {I}mmune {D}eficiency {S}yndromes},
  volume = {62},
  numero = {5},
  pages = {555--561},
  ISSN = {1525-4135},
  year = {2013},
  DOI = {10.1097/{QAI}.0b013e3182821821},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060382},
}