Horizon / Plein textes La base de ressources documentaires de l'IRD

IRD

Publications des scientifiques de l'IRD

Lo A. C., Faye B., Ba E. H., Cisse B., Tine R., Abiola A., Ndiaye M., Ndiaye J. L. A., Ndiaye D., Sokhna Cheikh, Gomis J. F., Dieng Y., Faye O., Ndir O., Milligan P., Cairns M., Hallett R., Sutherland C., Gaye O. (2013). Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal. Malaria Journal, 12, 137. ISSN 1475-2875

Fichier PDF disponible http://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010060347.pdf

Lien direct chez l'éditeur doi:10.1186/1475-2875-12-137

Titre
Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000318782200001
AuteursLo A. C., Faye B., Ba E. H., Cisse B., Tine R., Abiola A., Ndiaye M., Ndiaye J. L. A., Ndiaye D., Sokhna Cheikh, Gomis J. F., Dieng Y., Faye O., Ndir O., Milligan P., Cairns M., Hallett R., Sutherland C., Gaye O.
SourceMalaria Journal, 2013, 12, p. 137. p. 137 ISSN 1475-2875
RésuméBackground: In sub-Saharan Africa, malaria is the leading cause of morbidity and mortality especially in children. In Senegal, seasonal malaria chemoprevention (SMC) previously referred to as intermittent preventive treatment in children (IPTc) is a new strategy for malaria control in areas of high seasonal transmission. An effectiveness study of SMC, using sulphadoxine-pyrimethamine (SP) plus amodiaquine (AQ), was conducted in central Senegal from 2008 to 2010 to obtain information about safety, feasibility of delivery, and cost effectiveness of SMC. Here are report the effect of SMC delivery on the prevalence of markers of resistance to SP and AQ. Methods: This study was conducted in three health districts in Senegal with 54 health posts with a gradual introduction of SMC. Three administrations of the combination AQ + SP were made during the months of September, October and November of each year in children aged less than 10 years living in the area. Children were surveyed in December of each year and samples (filter paper and thick films) were made in 2008, 2009 and 2010. The prevalence of mutations in the pfdhfr, pfdhps, pfmdr1 and pfcrt genes was investigated by sequencing and RTPCR in samples positive by microscopy for Plasmodium falciparum. Results: Mutations at codon 540 of pfdhps and codon 164 of pfdhfr were not detected in the study. Among children with parasitaemia at the end of the transmission seasons, the CVIET haplotypes of pfcrt and the 86Y polymorphism of pfmdr1 were more common among those that had received SMC, but the number of infections detected was very low and confidence intervals were wide. The overall prevalence of these mutations was lower in SMC areas than in control areas, reflecting the lower prevalence of parasitaemia in areas where SMC was delivered. Conclusion: The sensitivity of P. falciparum to SMC drugs should be regularly monitored in areas deploying this intervention. Overall the prevalence of genotypes associated with resistance to either SP or AQ was lower in SMC areas due to the reduced number of parasitaemia individuals.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050]
Descr. géo.SENEGAL
LocalisationFonds IRD [F B010060347]
Identifiant IRDfdi:010060347
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010060347

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL


Accès aux documents originaux :

Le FDI est labellisé CollEx

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation

Bondy

Montpellier (centre IRD)

Montpellier (MSE)

Nouméa

Papeete

Niamey

Ouagadougou

Tunis

La Paz

Quito