@article{fdi:010060285,
  title = {{M}orphological and molecular characterization of dietary-induced pseudo-albinism during post-embryonic development of {S}olea senegalensis ({K}aup, 1858)},
  author = {{D}arias, {M}aria {J}ose and {A}ndree, {K}.{B}. and {B}oglino, {A}. and {R}otlant, {J}. and {C}erda-{R}everter, {J}.{M}. and {E}stevez, {A}. and {G}isbert, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he appearance of the pseudo-albino phenotype was investigated in developing {S}enegalese sole ({S}olea senegalensis, {K}aup 1858) larvae at morphological and molecular levels. {I}n order to induce the development of pseudo-albinos, {S}enegalese sole larvae were fed {A}rtemia enriched with high levels of arachidonic acid ({ARA}). {T}he development of their skin pigmentation was compared to that of a control group fed {A}rtemia enriched with a reference commercial product. {T}he relative amount of skin melanophores, xanthophores and iridophores revealed that larval pigmentation developed similarly in both groups. {H}owever, results from different relative proportions, allocation patterns, shapes and sizes of skin chromatophores revealed changes in the pigmentation pattern between {ARA} and control groups from 33 days post hatching onwards. {T}he new populations of chromatophores that should appear at post-metamorphosis were not formed in the {ARA} group. {F}urther, spatial patterns of distribution between the already present larval xanthophores and melanophores were suggestive of short-range interaction that seemed to be implicated in the degradation of these chromatophores, leading to the appearance of the pseudo-albino phenotype. {T}he expression profile of several key pigmentation-related genes revealed that melanophore development was promoted in pseudo-albinos without a sufficient degree of terminal differentiation, thus preventing melanogenesis. {P}resent results suggest the potential roles of asip1 and slc24a5 genes on the down-regulation of trp1 expression, leading to defects in melanin production. {M}oreover, gene expression data supports the involvement of pax3, mitf and asip1 genes in the developmental disruption of the new post-metamorphic populations of melanophores, xanthophores and iridophores.},
  keywords = {{POISSON} {MARIN} ; {PIGMENT} ; {LARVE} ; {ALIMENT} ; {PHENOTYPE} ; {GENE} ; {SOLE} ; {EXPRESSION} {DES} {GENES}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {8},
  numero = {7},
  pages = {e68844 [16 ]},
  ISSN = {1932-6203},
  year = {2013},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060285},
}