%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Khamduang, W.
%A Ngo-Giang-Huong, Nicole
%A Gaudy-Graffin, C.
%A Jourdain, Gonzague
%A Suwankornsakul, W.
%A Jarupanich, T.
%A Chalermpolprapa, V.
%A Nanta, S.
%A Puarattana-aroonkorn, N.
%A Tonmat, S.
%A Lallemant, Marc
%A Goudeau, A.
%A Sirirungsi, W.
%T Prevalence, risk factors, and impact of isolated antibody to hepatitis b core antigen and occult hepatitis b virus infection in hiv-1-infected pregnant women
%D 2013
%L fdi:010060135
%G ENG
%J Clinical Infectious Diseases
%@ 1058-4838
%K HIV-1-infected pregnant women ; isolated anti-HBc ; occult HBV infection ; perinatal transmission
%K THAILANDE
%M ISI:000319466600004
%N 12
%P 1704-1712
%R 10.1093/cid/cit166
%U https://www.documentation.ird.fr/hor/fdi:010060135
%> https://www.documentation.ird.fr/intranet/publi/depot/2013-10-28/010060135.pdf
%V 56
%W Horizon (IRD)
%X Background. Prevalence and risk factors for isolated antibody to hepatitis B core antigen (anti-HBc) and occult hepatitis B virus (HBV) infection are not well known in human immunodeficiency virus type 1 (HIV-1)-infected pregnant women. It is unclear if women with occult infections are at risk of transmitting HBV to their infants. Methods. HIV-1-infected and HBV surface antigen (HBsAg)-negative pregnant women were tested for anti-body to HBsAg (anti-HBs) and anti-HBc using enzyme immunoassay. Women with isolated anti-HBc were assessed for occult HBV infection, defined as HBV DNA levels >15 IU/mL, using the Abbott RealTime HBV DNA assay. Infants born to women with isolated anti-HBc and detectable HBV DNA were tested at 4 months of age for HBV DNA. Logistic regression analysis was used to identify factors associated with isolated anti-HBc and occult HBV infection. Results. Among 1812 HIV-infected pregnant women, 1682 were HBsAg negative. Fourteen percent (95% confidence interval [CI], 12%-15%) of HBsAg-negative women had an isolated anti-HBc that was independently associated with low CD4 count, age >35 years, birth in northern Thailand, and positive anti-hepatitis C virus serology. Occult HBV infection was identified in 24% (95% CI, 18%-30%) of women with isolated anti-HBc, representing 2.6% (95% CI, 1.9%-3.5%) of HIV-1-infected pregnant women, and was inversely associated with HIV RNA levels. None of the women with isolated anti-HBc and occult HBV infection transmitted HBV to their infants. Conclusions. HIV-1-infected pregnant women with isolated anti-HBc and occult HBV infection have very low HBV DNA levels and are thus at very low risk to transmit HBV to their infants.
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