@article{fdi:010060135,
  title = {{P}revalence, risk factors, and impact of isolated antibody to hepatitis b core antigen and occult hepatitis b virus infection in hiv-1-infected pregnant women},
  author = {{K}hamduang, {W}. and {N}go-{G}iang-{H}uong, {N}icole and {G}audy-{G}raffin, {C}. and {J}ourdain, {G}onzague and {S}uwankornsakul, {W}. and {J}arupanich, {T}. and {C}halermpolprapa, {V}. and {N}anta, {S}. and {P}uarattana-aroonkorn, {N}. and {T}onmat, {S}. and {L}allemant, {M}arc and {G}oudeau, {A}. and {S}irirungsi, {W}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {P}revalence and risk factors for isolated antibody to hepatitis {B} core antigen (anti-{HB}c) and occult hepatitis {B} virus ({HBV}) infection are not well known in human immunodeficiency virus type 1 ({HIV}-1)-infected pregnant women. {I}t is unclear if women with occult infections are at risk of transmitting {HBV} to their infants. {M}ethods. {HIV}-1-infected and {HBV} surface antigen ({HB}s{A}g)-negative pregnant women were tested for anti-body to {HB}s{A}g (anti-{HB}s) and anti-{HB}c using enzyme immunoassay. {W}omen with isolated anti-{HB}c were assessed for occult {HBV} infection, defined as {HBV} {DNA} levels >15 {IU}/m{L}, using the {A}bbott {R}eal{T}ime {HBV} {DNA} assay. {I}nfants born to women with isolated anti-{HB}c and detectable {HBV} {DNA} were tested at 4 months of age for {HBV} {DNA}. {L}ogistic regression analysis was used to identify factors associated with isolated anti-{HB}c and occult {HBV} infection. {R}esults. {A}mong 1812 {HIV}-infected pregnant women, 1682 were {HB}s{A}g negative. {F}ourteen percent (95% confidence interval [{CI}], 12%-15%) of {HB}s{A}g-negative women had an isolated anti-{HB}c that was independently associated with low {CD}4 count, age >35 years, birth in northern {T}hailand, and positive anti-hepatitis {C} virus serology. {O}ccult {HBV} infection was identified in 24% (95% {CI}, 18%-30%) of women with isolated anti-{HB}c, representing 2.6% (95% {CI}, 1.9%-3.5%) of {HIV}-1-infected pregnant women, and was inversely associated with {HIV} {RNA} levels. {N}one of the women with isolated anti-{HB}c and occult {HBV} infection transmitted {HBV} to their infants. {C}onclusions. {HIV}-1-infected pregnant women with isolated anti-{HB}c and occult {HBV} infection have very low {HBV} {DNA} levels and are thus at very low risk to transmit {HBV} to their infants.},
  keywords = {{HIV}-1-infected pregnant women ; isolated anti-{HB}c ; occult {HBV} infection ; perinatal transmission ; {THAILANDE}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {56},
  numero = {12},
  pages = {1704--1712},
  ISSN = {1058-4838},
  year = {2013},
  DOI = {10.1093/cid/cit166},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060135},
}