Khamduang W., Ngo-Giang-Huong Nicole, Gaudy-Graffin C., Jourdain Gonzague, Suwankornsakul W., Jarupanich T., Chalermpolprapa V., Nanta S., Puarattana-aroonkorn N., Tonmat S., Lallemant Marc, Goudeau A., Sirirungsi W. (2013). Prevalence, risk factors, and impact of isolated antibody to hepatitis b core antigen and occult hepatitis b virus infection in hiv-1-infected pregnant women. Clinical Infectious Diseases, 56 (12), p. 1704-1712. ISSN 1058-4838.
Titre du document
Prevalence, risk factors, and impact of isolated antibody to hepatitis b core antigen and occult hepatitis b virus infection in hiv-1-infected pregnant women
Année de publication
2013
Auteurs
Khamduang W., Ngo-Giang-Huong Nicole, Gaudy-Graffin C., Jourdain Gonzague, Suwankornsakul W., Jarupanich T., Chalermpolprapa V., Nanta S., Puarattana-aroonkorn N., Tonmat S., Lallemant Marc, Goudeau A., Sirirungsi W.
Source
Clinical Infectious Diseases, 2013,
56 (12), p. 1704-1712 ISSN 1058-4838
Background. Prevalence and risk factors for isolated antibody to hepatitis B core antigen (anti-HBc) and occult hepatitis B virus (HBV) infection are not well known in human immunodeficiency virus type 1 (HIV-1)-infected pregnant women. It is unclear if women with occult infections are at risk of transmitting HBV to their infants. Methods. HIV-1-infected and HBV surface antigen (HBsAg)-negative pregnant women were tested for anti-body to HBsAg (anti-HBs) and anti-HBc using enzyme immunoassay. Women with isolated anti-HBc were assessed for occult HBV infection, defined as HBV DNA levels >15 IU/mL, using the Abbott RealTime HBV DNA assay. Infants born to women with isolated anti-HBc and detectable HBV DNA were tested at 4 months of age for HBV DNA. Logistic regression analysis was used to identify factors associated with isolated anti-HBc and occult HBV infection. Results. Among 1812 HIV-infected pregnant women, 1682 were HBsAg negative. Fourteen percent (95% confidence interval [CI], 12%-15%) of HBsAg-negative women had an isolated anti-HBc that was independently associated with low CD4 count, age >35 years, birth in northern Thailand, and positive anti-hepatitis C virus serology. Occult HBV infection was identified in 24% (95% CI, 18%-30%) of women with isolated anti-HBc, representing 2.6% (95% CI, 1.9%-3.5%) of HIV-1-infected pregnant women, and was inversely associated with HIV RNA levels. None of the women with isolated anti-HBc and occult HBV infection transmitted HBV to their infants. Conclusions. HIV-1-infected pregnant women with isolated anti-HBc and occult HBV infection have very low HBV DNA levels and are thus at very low risk to transmit HBV to their infants.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
THAILANDE
Localisation
Fonds IRD [F B010060135]
Identifiant IRD
fdi:010060135
