%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ndounga, M.
%A Mayengue, P. I.
%A Casimiro, P. N.
%A Loumouamou, D.
%A Basco, Leonardo
%A Ntoumi, F.
%A Brasseur, P.
%T Artesunate-amodiaquine efficacy in Congolese children with acute uncomplicated falciparum malaria in Brazzaville
%D 2013
%L fdi:010058983
%G ENG
%J Malaria Journal
%@ 1475-2875
%K Drug resistance ; Artemisinin ; Combination therapy ; Chloroquine ; Drug efficacy ; Congo-Brazzaville
%K CONGO
%M ISI:000314679900001
%P 53
%R 10.1186/1475-2875-12-53
%U https://www.documentation.ird.fr/hor/fdi:010058983
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-09/010058983.pdf
%V 12
%W Horizon (IRD)
%X Background: Congo-Brazzaville adopted artemisinin-based combination therapy (ACT) in 2006. Artesunate-amodiaquine (AS + AQ) and artemether-lumefantrine are the first-line and second-line anti-malarial drugs to treat uncomplicated Plasmodium falciparum malaria, respectively. The baseline efficacy of AS + AQ was evaluated from February to August 2005 in patients living in Brazzaville, the capital city of the Republic of Congo. Methods: One hundred and ninety-seven patients (96 <= 5 years old and 101 > 5 years old, including adults) were recruited in a non-randomized study, treated under supervision with AS + AQ, and were followed up for 28 days in accordance with the 2003 World Health Organization protocol. Plasmodium falciparum recrudescent isolates from day 7 to day 28 were compared to pretreatment isolates by polymerase chain reaction (PCR) to distinguish between re-infection and recrudescence. Results: The overall efficacy of AS + AQ after PCR correction on day 28 was 94.4%. An adequate clinical and parasitological response was observed in 94.3% and 94.4% of children aged <= 5 years old and those aged > 5 years old (including adults), respectively. The main reported adverse events were dizziness, vomiting, diarrhoea, pruritus, headache, anorexia, and abdominal pain. Conclusion: This study has shown the high efficacy of AS + AQ in Congolese patients of all ages with acute uncomplicated falciparum malaria and serves as the baseline efficacy and tolerance of this ACT in Brazzaville.
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