%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Harrison, L.
%A Ananworanich, J.
%A Hamadache, D.
%A Compagnucci, A.
%A Penazzato, M.
%A Bunupuradah, T.
%A Mazza, A.
%A Ramos, J. T.
%A Flynn, J.
%A Rampon, O.
%A Pena, M. J. M.
%A Floret, D.
%A Marczynska, M.
%A Puga, A.
%A Forcat, S.
%A Riault, Y.
%A Lallemant, Marc
%A Castro, H.
%A Gibb, D. M.
%A Giaquinto, C.
%T Adherence to Antiretroviral Therapy and Acceptability of Planned Treatment Interruptions in HIV-Infected Children
%D 2013
%L fdi:010058958
%G ENG
%J Aids and Behavior
%@ 1090-7165
%K Adherence ; Acceptability ; Planned treatment interruptions ; HIV ; Children
%K THAILANDE ; EUROPE ; ETATS UNIS
%M ISI:000313734000020
%N 1
%P 193-202
%R 10.1007/s10461-012-0197-y
%U https://www.documentation.ird.fr/hor/fdi:010058958
%> https://www.documentation.ird.fr/intranet/publi/2013/02/010058958.pdf
%V 17
%W Horizon (IRD)
%X There have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA 11, HIV-infected children were randomised to CD4-guided PTIs (n = 53) or continuous therapy (CT, n = 56). Carers, and children if appropriate, completed questionnaires on adherence to ART and acceptability of PTIs. There was no difference in reported adherence on ART between CT and PTI groups; non-adherence (reporting missed doses over the last 3 days or marking < 100 % adherence since the last clinical visit on a visual analogue scale) was 18 % (20/111) and 14 % (12/83) on carer questionnaires in the CT and PTI groups respectively (odds ratios, OR (95 % CI) = 1.04 (0.20, 5.41), chi(2) (1) = 0.003, p = 0.96). Carers in Europe/USA reported non-adherence more often (31/121, 26 %) than in Thailand (1/73, 1 %; OR (95 % CI) = 54.65 (3.68, 810.55), chi(2) (1) = 8.45, p = 0.004). The majority of families indicated they were happy to have further PTIs (carer: 23/36, 64 %; children: 8/13, 62 %), however many reported more clinic visits during PTI were a problem (carer: 15/36, 42 %; children: 6/12, 50 %).
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