@article{fdi:010058958,
  title = {{A}dherence to {A}ntiretroviral {T}herapy and {A}cceptability of {P}lanned {T}reatment {I}nterruptions in {HIV}-{I}nfected {C}hildren},
  author = {{H}arrison, {L}. and {A}nanworanich, {J}. and {H}amadache, {D}. and {C}ompagnucci, {A}. and {P}enazzato, {M}. and {B}unupuradah, {T}. and {M}azza, {A}. and {R}amos, {J}. {T}. and {F}lynn, {J}. and {R}ampon, {O}. and {P}ena, {M}. {J}. {M}. and {F}loret, {D}. and {M}arczynska, {M}. and {P}uga, {A}. and {F}orcat, {S}. and {R}iault, {Y}. and {L}allemant, {M}arc and {C}astro, {H}. and {G}ibb, {D}. {M}. and {G}iaquinto, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}here have been no paediatric randomised trials describing the effect of planned treatment interruptions ({PTI}s) of antiretroviral therapy ({ART}) on adherence, or evaluating acceptability of such a strategy. {I}n {PENTA} 11, {HIV}-infected children were randomised to {CD}4-guided {PTI}s (n = 53) or continuous therapy ({CT}, n = 56). {C}arers, and children if appropriate, completed questionnaires on adherence to {ART} and acceptability of {PTI}s. {T}here was no difference in reported adherence on {ART} between {CT} and {PTI} groups; non-adherence (reporting missed doses over the last 3 days or marking < 100 % adherence since the last clinical visit on a visual analogue scale) was 18 % (20/111) and 14 % (12/83) on carer questionnaires in the {CT} and {PTI} groups respectively (odds ratios, {OR} (95 % {CI}) = 1.04 (0.20, 5.41), chi(2) (1) = 0.003, p = 0.96). {C}arers in {E}urope/{USA} reported non-adherence more often (31/121, 26 %) than in {T}hailand (1/73, 1 %; {OR} (95 % {CI}) = 54.65 (3.68, 810.55), chi(2) (1) = 8.45, p = 0.004). {T}he majority of families indicated they were happy to have further {PTI}s (carer: 23/36, 64 %; children: 8/13, 62 %), however many reported more clinic visits during {PTI} were a problem (carer: 15/36, 42 %; children: 6/12, 50 %).},
  keywords = {{A}dherence ; {A}cceptability ; {P}lanned treatment interruptions ; {HIV} ; {C}hildren ; {THAILANDE} ; {EUROPE} ; {ETATS} {UNIS}},
  booktitle = {},
  journal = {{A}ids and {B}ehavior},
  volume = {17},
  numero = {1},
  pages = {193--202},
  ISSN = {1090-7165},
  year = {2013},
  DOI = {10.1007/s10461-012-0197-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058958},
}