Adherence to Antiretroviral Therapy and Acceptability of Planned Treatment Interruptions in HIV-Infected Children

2013

Article référencé dans le Web of Science WOS:000313734000020

Harrison L., Ananworanich J., Hamadache D., Compagnucci A., Penazzato M., Bunupuradah T., Mazza A., Ramos J. T., Flynn J., Rampon O., Pena M. J. M., Floret D., Marczynska M., Puga A., Forcat S., Riault Y., Lallemant Marc, Castro H., Gibb D. M., Giaquinto C.

Aids and Behavior, 2013, 17 (1), p. 193-202 ISSN 1090-7165

There have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA 11, HIV-infected children were randomised to CD4-guided PTIs (n = 53) or continuous therapy (CT, n = 56). Carers, and children if appropriate, completed questionnaires on adherence to ART and acceptability of PTIs. There was no difference in reported adherence on ART between CT and PTI groups; non-adherence (reporting missed doses over the last 3 days or marking < 100 % adherence since the last clinical visit on a visual analogue scale) was 18 % (20/111) and 14 % (12/83) on carer questionnaires in the CT and PTI groups respectively (odds ratios, OR (95 % CI) = 1.04 (0.20, 5.41), chi(2) (1) = 0.003, p = 0.96). Carers in Europe/USA reported non-adherence more often (31/121, 26 %) than in Thailand (1/73, 1 %; OR (95 % CI) = 54.65 (3.68, 810.55), chi(2) (1) = 8.45, p = 0.004). The majority of families indicated they were happy to have further PTIs (carer: 23/36, 64 %; children: 8/13, 62 %), however many reported more clinic visits during PTI were a problem (carer: 15/36, 42 %; children: 6/12, 50 %).

Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]

THAILANDE ; EUROPE ; ETATS UNIS

Fonds IRD [F B010058958]

fdi:010058958