Publications des scientifiques de l'IRD

Thomas F., Fisher D., Fort P., Marie J. P., Daoust S., Roche Benjamin, Grunau C., Cosseau C., Mitta G., Baghdiguian S., Rousset F., Lassus P., Assenat E., Grégoire D., Missé Dorothée, Lorz A., Billy F., Vainchenker W., Delhommeau F., Koscielny S., Itzykson R., Tang R. P., Fava F., Ballesta A., Lepoutre T., Krasinska L., Dulic V., Raynaud P., Blache P., Quittau-Prevostel C., Vignal E., Trauchessec H., Perthame B., Clairambault J., Volpert V., Solary E., Hibner U., Hochberg M. E. (2013). Applying ecological and evolutionary theory to cancer : a long and winding road. Evolutionary Applications, 6 (1), p. 1-10. ISSN 1752-4571.

Titre du document
Applying ecological and evolutionary theory to cancer : a long and winding road
Année de publication
2013
Type de document
Article référencé dans le Web of Science WOS:000313878800001
Auteurs
Thomas F., Fisher D., Fort P., Marie J. P., Daoust S., Roche Benjamin, Grunau C., Cosseau C., Mitta G., Baghdiguian S., Rousset F., Lassus P., Assenat E., Grégoire D., Missé Dorothée, Lorz A., Billy F., Vainchenker W., Delhommeau F., Koscielny S., Itzykson R., Tang R. P., Fava F., Ballesta A., Lepoutre T., Krasinska L., Dulic V., Raynaud P., Blache P., Quittau-Prevostel C., Vignal E., Trauchessec H., Perthame B., Clairambault J., Volpert V., Solary E., Hibner U., Hochberg M. E.
Source
Evolutionary Applications, 2013, 6 (1), p. 1-10 ISSN 1752-4571
Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Santé : généralités [050]
Localisation
Fonds IRD [F B010058930]
Identifiant IRD
fdi:010058930
Contact