@article{fdi:010057318,
  title = {{N}atural resistance to cancers : a {D}arwinian hypothesis to explain {P}eto's paradox},
  author = {{R}oche, {B}enjamin and {H}ochberg, {M}. {E}. and {C}aulin, {A}. {F}. and {M}aley, {C}. {C}. and {G}atenby, {R}. {A}. and {M}iss{\'e}, {D}oroth{\'e}e and {T}homas, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {P}eto's paradox stipulates that there is no association between body mass (a surrogate of number of cells and longevity) and cancer prevalence in wildlife species. {R}esolving this paradox is a very promising research direction to understand mechanisms of cancer resistance. {A}s of present, research has been focused on the consequences of these evolutionary pressures rather than of their causes. {D}iscussion: {H}ere, we argue that evolution through natural selection may have shaped mechanisms of cancer resistance in wildlife species and that this can result in a threshold in body mass above which oncogenic and tumor suppressive mechanisms should be increasingly purified and positively selected, respectively. {S}ummary: {W}e conclude that assessing wildlife species in their natural ecosystems, especially through theoretical modeling, is the most promising way to understand how evolutionary processes can favor one or the other pathway. {T}his will provide important insights into mechanisms of cancer resistance.},
  keywords = {},
  booktitle = {},
  journal = {{B}mc {C}ancer},
  volume = {12},
  numero = {},
  pages = {387},
  ISSN = {1471-2407},
  year = {2012},
  DOI = {10.1186/1471-2407-12-387},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057318},
}