@article{fdi:010057058,
  title = {{S}hort synthesis and antimalarial activity of fagaronine},
  author = {{R}ivaud, {M}. and {M}endoza, {A}. and {S}auvain, {M}ichel and {V}alentin, {A}. and {J}ullian, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{H}erein, we report a new synthesis of fagaronine 1, inspired by the synthesis reported by {L}uo for nornitidine. {T}he in vitro biological activity of fagaronine against malaria on several chloroquine-sensitive and resistant {P}lasmodium falciparum strains was confirmed, and the selectivity index compared to mammalian cells was calculated. {F}agaronine was found to have very good antimalarial activity in vivo, comparable to the activity of the reference compound chloroquine. {T}herefore, fagaronine appears to be a good potential lead for the design of new antimalarial molecules.},
  keywords = {{F}agaronine ; {B}enzo[c]phenanthridine ; {S}ynthesis ; {M}alaria ; {I}n vivo experiment},
  booktitle = {},
  journal = {{B}ioorganic and {M}edicinal {C}hemistry},
  volume = {20},
  numero = {15},
  pages = {4856--4861},
  ISSN = {0968-0896},
  year = {2012},
  DOI = {10.1016/j.bmc.2012.05.061},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057058},
}