%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Zampella, A.
%A Sepe, V.
%A Bellotta, F.
%A Luciano, P.
%A D'Auria, M. V.
%A Cresteil, T.
%A Debitus, Cécile
%A Petek, Sylvain
%A Poupat, C.
%A Ahond, A.
%T Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.
%D 2009
%L fdi:010056917
%G ENG
%J Organic and Biomolecular Chemistry
%@ 1477-0520
%M ISI:000269892900022
%N 19
%P 4037-4044
%R 10.1039/b910015f
%U https://www.documentation.ird.fr/hor/fdi:010056917
%> https://www.documentation.ird.fr/intranet/publi/depot/2012-09-11/010056917.pdf
%V 7
%W Horizon (IRD)
%X Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.
%$ 035