Publications des scientifiques de l'IRD

Zampella A., Sepe V., Bellotta F., Luciano P., D'Auria M. V., Cresteil T., Debitus Cécile, Petek Sylvain, Poupat C., Ahond A. (2009). Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.. Organic and Biomolecular Chemistry, 7 (19), p. 4037-4044. ISSN 1477-0520.

Titre du document
Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.
Année de publication
2009
Type de document
Article référencé dans le Web of Science WOS:000269892900022
Auteurs
Zampella A., Sepe V., Bellotta F., Luciano P., D'Auria M. V., Cresteil T., Debitus Cécile, Petek Sylvain, Poupat C., Ahond A.
Source
Organic and Biomolecular Chemistry, 2009, 7 (19), p. 4037-4044 ISSN 1477-0520
Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.
Plan de classement
Substances naturelles [035]
Localisation
Fonds IRD [F B010056917]
Identifiant IRD
fdi:010056917
Contact