Zampella A., Sepe V., Bellotta F., Luciano P., D'Auria M. V., Cresteil T., Debitus Cécile, Petek Sylvain, Poupat C., Ahond A. (2009). Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.. Organic and Biomolecular Chemistry, 7 (19), p. 4037-4044. ISSN 1477-0520.
Titre du document
Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.
Zampella A., Sepe V., Bellotta F., Luciano P., D'Auria M. V., Cresteil T., Debitus Cécile, Petek Sylvain, Poupat C., Ahond A.
Source
Organic and Biomolecular Chemistry, 2009,
7 (19), p. 4037-4044 ISSN 1477-0520
Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.