@article{fdi:010055957,
  title = {{M}idgut microbiota of the malaria mosquito vector {A}nopheles gambiae and interactions with {P}lasmodium falciparum infection},
  author = {{B}oissiere, {A}nne and {T}chioffo, {M}. {T}. and {B}achar, {D}. and {A}bate, {L}uc and {M}arie, {A}. and {N}sango, {S}. {E}. and {S}hahbazkia, {H}. {R}. and {A}wono-{A}mbene, {P}. {H}. and {L}evashina, {E}. {A}. and {C}hristen, {R}. and {M}orlais, {I}sabelle},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he susceptibility of {A}nopheles mosquitoes to {P}lasmodium infections relies on complex interactions between the insect vector and the malaria parasite. {A} number of studies have shown that the mosquito innate immune responses play an important role in controlling the malaria infection and that the strength of parasite clearance is under genetic control, but little is known about the influence of environmental factors on the transmission success. {W}e present here evidence that the composition of the vector gut microbiota is one of the major components that determine the outcome of mosquito infections. {A}. gambiae mosquitoes collected in natural breeding sites from {C}ameroon were experimentally challenged with a wild {P}. falciparum isolate, and their gut bacterial content was submitted for pyrosequencing analysis. {T}he meta-taxogenomic approach revealed a broader richness of the midgut bacterial flora than previously described. {U}nexpectedly, the majority of bacterial species were found in only a small proportion of mosquitoes, and only 20 genera were shared by 80% of individuals. {W}e show that observed differences in gut bacterial flora of adult mosquitoes is a result of breeding in distinct sites, suggesting that the native aquatic source where larvae were grown determines the composition of the midgut microbiota. {I}mportantly, the abundance of {E}nterobacteriaceae in the mosquito midgut correlates significantly with the {P}lasmodium infection status. {T}his striking relationship highlights the role of natural gut environment in parasite transmission. {D}eciphering microbe-pathogen interactions offers new perspectives to control disease transmission.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {P}athogens},
  volume = {8},
  numero = {5},
  pages = {e1002742},
  ISSN = {1553-7374},
  year = {2012},
  DOI = {10.1371/journal.ppat.1002742},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055957},
}