@article{fdi:010055873,
  title = {{C}ontrasted patterns of selection on {MHC}-linked microsatellites in natural populations of the {M}alagasy plague reservoir},
  author = {{T}ollenaere, {C}harlotte and {I}vanova, {S}. and {D}uplantier, {J}ean-{M}arc and {L}oiseau, {A}. and {R}ahalison, {L}. and {R}ahelinirina, {S}. and {B}rouat, {C}arine},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lague ({Y}ersinia pestis infection) is a highly virulent rodent disease that persists in many natural ecosystems. {T}he black rat ({R}attus rattus) is the main host involved in the plague focus of the central highlands of {M}adagascar. {B}lack rat populations from this area are highly resistant to plague, whereas those from areas in which the disease is absent (low altitude zones of {M}adagascar) are susceptible. {V}arious lines of evidence suggest a role for the {M}ajor {H}istocompatibility {C}omplex ({MHC}) in plague resistance. {W}e therefore used the {MHC} region as a candidate for detecting signatures of plague-mediated selection in {M}alagasy black rats, by comparing population genetic structures for five {MHC}-linked microsatellites and neutral markers in two sampling designs. {W}e first compared four pairs of populations, each pair including one population from the plague focus and one from the disease-free zone. {P}lague-mediated selection was expected to result in greater genetic differentiation between the two zones than expected under neutrality and this was observed for one {MHC}-class {I}-linked locus ({D}20{I}mg2). {F}or this marker as well as for four other {MHC}-linked loci, a geographic pattern of genetic structure was found at local scale within the plague focus. {T}his pattern would be expected if plague selection pressures were spatially variable. {F}inally, another {MHC}-class {I}-linked locus ({D}20{R}at21) showed evidences of balancing selection, but it seems more likely that this selection would be related to unknown pathogens more widely distributed in {M}adagascar than plague.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {7},
  numero = {3},
  pages = {e32814},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0032814},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055873},
}