@article{fdi:010055866, title = {{P}ipestelides {A}-{C} : cyclodepsipeptides from the {P}acific marine sponge {P}ipestela candelabra}, author = {{S}orres, {J}. and {M}artin, {M}. {T}. and {P}etek, {S}ylvain and {L}evaique, {H}. and {C}resteil, {T}. and {R}amos, {S}. and {T}hoison, {O}. and {D}ebitus, {C}{\'e}cile and {A}l-{M}ourabit, {A}.}, editor = {}, language = {{ENG}}, abstract = {{P}ipestelides {A}-{C} (2-4) are three new {NRPS}-{PKS} hybrid macrolides containing uncommon moieties, isolated from the {P}acific marine sponge {P}ipestela candelabra. {T}heir structures were elucidated on the basis of spectroscopic data. {T}hese cyclodepsipeptides appear to be biosynthetically related to jaspamide (aka jasplakinolide) (1) by chemical modification of the building blocks of the polyketide or peptide chains. {P}ipestelides {A}-{C} (2-4) contain a bromotyrosine [3-amino-3-(bromo-4-hydroxyphenyl)propanoic acid] unit, a polypropionate with a {Z} double bond, and a 2-hydroxyquinolinone, respectively. {R}evised chemical shift assignments are provided for the co-isolated known jasplakinolide {C}-a (5). {I}n addition, compounds 2 and 3 exhibited cytotoxic activities in the micromolar range.}, keywords = {}, booktitle = {}, journal = {{J}ournal of {N}atural {P}roducts}, volume = {75}, numero = {4}, pages = {759--763}, ISSN = {0163-3864}, year = {2012}, DOI = {10.1021/np200714m}, URL = {https://www.documentation.ird.fr/hor/fdi:010055866}, }