%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Magid, A. A.
%A Lalun, N.
%A Long, C.
%A Borie, N.
%A Bobichon, H.
%A Moretti, Christian
%A Lavaud, C.
%T Triterpene saponins from Antonia ovata leaves
%D 2012
%L fdi:010055843
%G ENG
%J Phytochemistry
%@ 0031-9422
%K Antonia ovata ; Loganiaceae ; Triterpenoid saponins ; Theasapogenol A ; 15 alpha-Hydroxy-theasapogenol A ; Cytotoxic activity
%M ISI:000303273300027
%P 268-274
%R 10.1016/j.phytochem.2012.01.025
%U https://www.documentation.ird.fr/hor/fdi:010055843
%> https://www.documentation.ird.fr/intranet/publi/2012/05/010055843.pdf
%V 77
%W Horizon (IRD)
%X Six pentacyclic triterpenoid saponins, named antoniosides E-J along with two known alkaloids, were isolated from the leaves of Antonia ovata. Their structures were determined by the extensive use of 1D and 2D-NMR experiments along with HRESIMS analysis and acid hydrolysis. All isolated saponins contained the same pentasaccharide chain: 3-O-[beta-D-glucopyranosyl-(1 -> 2)]-[beta-D-glucopyranosyl-(1 -> 4)]-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl(1 -> 6)]-beta-D-glucopyranoside, linked at C-3 of esterified derivatives of polyhydroxyoleanene triterpenoids (theasapogenol A and 15 alpha-hydroxy-theasapogenol A). Isolated compounds were evaluated for their cytotoxic activity against KB cell line by a WST-1 assay, and the IC50 values ranged from 3.3 to 5.3 mu M.
%$ 076