Triterpene saponins from Antonia ovata leaves Magid, A. A. Lalun, N. Long, C. Borie, N. Bobichon, H. /Moretti, Christian Lavaud, C. Antonia ovata Loganiaceae Triterpenoid saponins Theasapogenol A 15 alpha-Hydroxy-theasapogenol A Cytotoxic activity Six pentacyclic triterpenoid saponins, named antoniosides E-J along with two known alkaloids, were isolated from the leaves of Antonia ovata. Their structures were determined by the extensive use of 1D and 2D-NMR experiments along with HRESIMS analysis and acid hydrolysis. All isolated saponins contained the same pentasaccharide chain: 3-O-[beta-D-glucopyranosyl-(1 -> 2)]-[beta-D-glucopyranosyl-(1 -> 4)]-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl(1 -> 6)]-beta-D-glucopyranoside, linked at C-3 of esterified derivatives of polyhydroxyoleanene triterpenoids (theasapogenol A and 15 alpha-hydroxy-theasapogenol A). Isolated compounds were evaluated for their cytotoxic activity against KB cell line by a WST-1 assay, and the IC50 values ranged from 3.3 to 5.3 mu M. 2012 text https://www.documentation.ird.fr/hor/fdi:010055843 fdi:010055843 Magid A. A., Lalun N., Long C., Borie N., Bobichon H., Moretti Christian, Lavaud C.. Triterpene saponins from Antonia ovata leaves. 2012, 77, 268-274 EN