Zampella A., Sepe V., Luciano P., Bellotta F., Monti M. C., Auria D' M. V., Jepsen T., Petek S., Adeline M. T., Laprevote O., Aubertin A. M., Debitus Cécile, Poupat C., Ahond A. (2008). Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp. Journal of Organic Chemistry, 73 (14), p. 5319-5327. ISSN 0022-3263.
Titre du document
Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp
Année de publication
2008
Auteurs
Zampella A., Sepe V., Luciano P., Bellotta F., Monti M. C., Auria D' M. V., Jepsen T., Petek S., Adeline M. T., Laprevote O., Aubertin A. M., Debitus Cécile, Poupat C., Ahond A.
Source
Journal of Organic Chemistry, 2008,
73 (14), p. 5319-5327 ISSN 0022-3263
A new anti-HIV cyclodepsipeptide, homophymine A, was isolated from a New Caledonian collection of the marine sponge Homophymia sp. The structure of homophymine A was determined by interpretation of spectroscopic data, acid hydrolysis, and LC-MS analysis. Homophymine A contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6-trimethyloctanoic acid moiety. Along with four D-, two L-, and one N-methyl arnino acids, it also contains four unusual amino acid residues: (2S,3S,4R)-3,4diMe-Gln, (2R,3R,4S)-4-amino-2,3-dihydroxy-1,7-heptandioic acid, L-ThrOMe, and (2R,3R,4R)-2-amino3-hydroxy-4,5-dimethylhexanoic acid. In a cell-based XTT assay, homophymine A exhibited cytoprotective activity against HIV-1 infection with a IC50 of 75 nM.
Plan de classement
Substances naturelles [035]
Description Géographique
NOUVELLE CALEDONIE
Localisation
Fonds IRD [F B010055302]
Identifiant IRD
fdi:010055302
