@article{fdi:010054136,
  title = {{G}enomotyping of {C}oxiella burnetii using microarrays reveals a conserved genomotype for hard tick isolates},
  author = {{L}eroy, {Q}. and {A}rmougom, {F}abrice and {B}arbry, {P}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{C}. burnetii is a {G}ram-negative intracellular {Y}-proteobacteria that causes the zoonotic disease {Q} fever. {Q} fever can manifest as an acute or chronic illness. {D}ifferent typing methods have been previously developed to classify {C}. burnetii isolates to explore its pathogenicity. {H}ere, we report a comprehensive genomotyping method based on the presence or absence of genes using microarrays. {T}he genomotyping method was then tested in 52 isolates obtained from different geographic areas, different hosts and patients with different clinical manifestations. {T}he analysis revealed the presence of 10 genomotypes organized into 3 groups, with a topology congruent with that obtained through multi-spacer typing. {W}e also found that only 4 genomotypes were specifically associated with acute {Q} fever, whereas all of the genomotypes could be associated to chronic human infection. {S}erendipitously, the genomotyping results revealed that all hard tick isolates, including the {N}ine {M}ile strain, belong to the same genomotype.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {6},
  numero = {10},
  pages = {e25781},
  ISSN = {1932-6203},
  year = {2011},
  DOI = {10.1371/journal.pone.0025781},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054136},
}