%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Petitdemange, C.
%A Becquart, Pierre
%A Wauquier, N.
%A Beziat, V.
%A Debre, P.
%A Leroy, Eric
%A Vieillard, V.
%T Unconventional repertoire profile is imprinted during acute chikungunya infection for natural killer cells polarization toward cytotoxicity
%D 2011
%L fdi:010053887
%G ENG
%J Plos Pathogens
%@ 1553-7366
%M ISI:000295409000068
%N 9
%P e1002268
%R 10.1371/journal.ppat.1002268
%U https://www.documentation.ird.fr/hor/fdi:010053887
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-09/010053887.pdf
%V 7
%W Horizon (IRD)
%X Chikungunya virus (CHIKV) is a worldwide emerging pathogen. In humans it causes a syndrome characterized by high fever, polyarthritis, and in some cases lethal encephalitis. Growing evidence indicates that the innate immune response plays a role in controlling CHIKV infection. We show here that CHIKV induces major but transient modifications in NK-cell phenotype and function soon after the onset of acute infection. We report a transient clonal expansion of NK cells that coexpress CD94/NKG2C and inhibitory receptors for HLA-C1 alleles and are correlated with the viral load. Functional tests reveal cytolytic capacity driven by NK cells in the absence of exogenous signals and severely impaired IFN-gamma production. Collectively these data provide insight into the role of this unique subset of NK cells in controlling CHIKV infection by subset-specific expansion in response to acute infection, followed by a contraction phase after viral clearance.
%$ 052