@article{fdi:010053887,
  title = {{U}nconventional repertoire profile is imprinted during acute chikungunya infection for natural killer cells polarization toward cytotoxicity},
  author = {{P}etitdemange, {C}. and {B}ecquart, {P}ierre and {W}auquier, {N}. and {B}eziat, {V}. and {D}ebre, {P}. and {L}eroy, {E}ric and {V}ieillard, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}hikungunya virus ({CHIKV}) is a worldwide emerging pathogen. {I}n humans it causes a syndrome characterized by high fever, polyarthritis, and in some cases lethal encephalitis. {G}rowing evidence indicates that the innate immune response plays a role in controlling {CHIKV} infection. {W}e show here that {CHIKV} induces major but transient modifications in {NK}-cell phenotype and function soon after the onset of acute infection. {W}e report a transient clonal expansion of {NK} cells that coexpress {CD}94/{NKG}2{C} and inhibitory receptors for {HLA}-{C}1 alleles and are correlated with the viral load. {F}unctional tests reveal cytolytic capacity driven by {NK} cells in the absence of exogenous signals and severely impaired {IFN}-gamma production. {C}ollectively these data provide insight into the role of this unique subset of {NK} cells in controlling {CHIKV} infection by subset-specific expansion in response to acute infection, followed by a contraction phase after viral clearance.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {P}athogens},
  volume = {7},
  numero = {9},
  pages = {e1002268},
  ISSN = {1553-7366},
  year = {2011},
  DOI = {10.1371/journal.ppat.1002268},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053887},
}