@article{fdi:010053664,
  title = {{B}ioactive indole derivatives from the {S}outh {P}acific marine sponges {R}hopaloeides odorabile and {H}yrtios sp},
  author = {{L}ongeon, {A}. and {C}opp, {B}. {R}. and {Q}uevrain, {E}. and {R}ou{\'e}, {M}. and {K}ientz, {B}. and {C}resteil, {T}. and {P}etek, {S}ylvain and {D}ebitus, {C}{\'e}cile and {B}ourguet-{K}ondracki, {M}. {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ndole derivatives including bromoindoles have been isolated from the {S}outh {P}acific marine sponges {R}hopaloeides odorabile and {H}yrtios sp. {T}heir structures were established through analysis of mass spectra and 1{D} and 2{D} {NMR} spectroscopic data. {T}heir potential inhibitory phospholipase {A}(2) ({PLA}(2)), antioxidant and cytotoxic activities were evaluated. {T}he new derivative 5,6-dibromo-{L}-hypaphorine (9) isolated from {H}yrtios sp. revealed a weak bee venom {PLA}2 inhibition ({IC}50 0.2 m{M}) and a significant antioxidant activity with an {O}xygen {R}adical {A}bsorbance {C}apacity ({ORAC}) value of 0.22. {T}he sesquiterpene aureol (4), also isolated from {H}yrtios sp., showed the most potent antioxidant activity with an {ORAC} value of 0.29.},
  keywords = {indole derivatives ; bromoindoles ; marine sponge ; {R}hopaloeides ; odorabile ; {H}yrtios sp. ; {PLA}(2) inhibitor ; antioxidant ; cytotoxic},
  booktitle = {},
  journal = {{M}arine {D}rugs},
  volume = {9},
  numero = {5},
  pages = {879--888},
  ISSN = {1660-3397},
  year = {2011},
  DOI = {10.3390/md9050879},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053664},
}