Publications des scientifiques de l'IRD

Longeon A., Copp B. R., Quevrain E., Roué M., Kientz B., Cresteil T., Petek Sylvain, Debitus Cécile, Bourguet-Kondracki M. L. (2011). Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Marine Drugs, 9 (5), p. 879-888. ISSN 1660-3397.

Titre du document
Bioactive indole derivatives from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp
Année de publication
2011
Type de document
Article référencé dans le Web of Science WOS:000292632500015
Auteurs
Longeon A., Copp B. R., Quevrain E., Roué M., Kientz B., Cresteil T., Petek Sylvain, Debitus Cécile, Bourguet-Kondracki M. L.
Source
Marine Drugs, 2011, 9 (5), p. 879-888 ISSN 1660-3397
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A(2) (PLA(2)), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA2 inhibition (IC50 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
Plan de classement
Substances naturelles [035]
Localisation
Fonds IRD [F B010053664]
Identifiant IRD
fdi:010053664
Contact