@article{fdi:010053634,
  title = {{I}nnate immune responses of a scleractinian coral to vibriosis},
  author = {{V}idal-{D}upiol, {J}. and {L}adri{\`e}re, {O}. and {D}estoumieux {G}arzon, {D}. and {S}auti{\`e}re, {P}. {E}. and {M}eistertzheim, {A}. {L}. and {T}ambutt{\'e}, {E}. and {T}ambutt{\'e}, {S}. and {D}uval, {D}. and {F}our{\'e}, {L}. and {A}djeroud, {M}ehdi and {M}itta, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}cleractinian corals are the most basal eumetazoan taxon and provide the biological and physical framework for coral reefs, which are among the most diverse of all ecosystems. {O}ver the past three decades and coincident with climate change, these phototrophic symbiotic organisms have been subject to increasingly frequent and severe diseases, which are now geographically widespread and a major threat to these ecosystems. {A}lthough coral immunity has been the subject of increasing study, the available information remains fragmentary, especially with respect to coral antimicrobial responses. {I}n this study, we characterized damicornin from {P}ocillopora damicornis, the first scleractinian antimicrobial peptide ({AMP}) to be reported. {W}e found that its precursor has a segmented organization comprising a signal peptide, an acidic proregion, and the {C}-terminal {AMP}. {T}he 40-residue {AMP} is cationic, {C}-terminally amidated, and characterized by the presence of six cysteine molecules joined by three intramolecular disulfide bridges. {I}ts cysteine array is common to another {AMP} and toxins from cnidarians; this suggests a common ancestor, as has been proposed for {AMP}s and toxins from arthropods. {D}amicornin was active in vitro against {G}ram-positive bacteria and the fungus {F}usarium oxysporum. {D}amicornin expression was studied using a combination of immunohistochemistry, reverse phase {HPLC}, and quantitative {RT}-{PCR}. {O}ur data show that damicornin is constitutively transcribed in ectodermal granular cells, where it is stored, and further released in response to nonpathogenic immune challenge. {D}amicornin gene expression was repressed by the coral pathogen {V}ibrio coralliilyticus. {T}his is the first evidence of {AMP} gene repression in a host-{V}ibrio interaction.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {B}iological {C}hemistry},
  volume = {286},
  numero = {25},
  pages = {22688--22698},
  ISSN = {0021-9258},
  year = {2011},
  DOI = {10.1074/jbc.{M}110.216358},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053634},
}