@article{fdi:010053428,
  title = {{H}uman immune responses that reduce the transmission of {P}lasmodium falciparum in {A}frican populations},
  author = {{B}ousema, {T}. and {S}utherland, {C}. {J}. and {C}hurcher, {T}. {S}. and {M}ulder, {B}. and {G}ouagna, {L}ouis-{C}l{\'e}ment and {R}iley, {E}. {M}. and {T}argett, {G}. {A}. {T}. and {D}rakeley, {C}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria-infected individuals can develop antibodies which reduce the infectiousness of {P}lasmodium gametocytes to biting {A}nopheles mosquitoes. {W}hen ingested in a bloodmeal together with gametocytes, these antibodies reduce or prevent subsequent parasite maturation in the insect host. {T}his transmission-blocking immunity is usually measured in human sera by testing its effect on the infectivity of gametocytes grown in vitro. {H}ere we evaluate evidence of transmission-blocking immunity in eight studies conducted in three {A}frican countries. {P}lasmodium falciparum gametocytes isolated from each individual were fed to mosquitoes in both autologous plasma collected with the parasites, and permissive serum from non-exposed donors. {E}vidence of transmission reducing effects of autologous plasma was found in all countries. {E}xperiments involving 116 {G}ambian children (aged 0.5-15 years) were combined to determine which factors were associated with transmission reducing immune responses. {T}he chances of infecting at least one mosquito and the average proportion of infected mosquitoes were negatively associated with recent exposure to gametocytes and sampling late in the season. {T}hese results suggest that effective malaria transmission-reducing antibodies do not commonly circulate in {A}frican children, and that recent gametocyte carriage is required to initiate and/or boost such responses.},
  keywords = {{M}embrane feeding ; {M}alaria ; {S}exual stage immunity ; {A}cquisition ; {L}ongevity ; {D}ynamics ; {P}fs48/45 ; {P}fs230},
  booktitle = {},
  journal = {{I}nternational {J}ournal for {P}arasitology},
  volume = {41},
  numero = {3-4},
  pages = {293--300},
  ISSN = {0020-7519},
  year = {2011},
  DOI = {10.1016/j.ijpara.2010.09.908},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053428},
}