@article{fdi:010053133,
  title = {{AFLP} genome scan in the black rat ({R}attus rattus) from {M}adagascar : detecting genetic markers undergoing plague-mediated selection},
  author = {{T}ollenaere, {C}harlotte and {D}uplantier, {J}ean-{M}arc and {R}ahalison, {L}. and {R}anjalahy, {M}. and {B}rouat, {C}arine},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he black rat ({R}attus rattus) is the main reservoir of plague ({Y}ersinia pestis infection) in {M}adagascar's rural zones. {B}lack rats are highly resistant to plague within the plague focus (central highland), whereas they are susceptible where the disease is absent (low altitude zone). {T}o better understand plague wildlife circulation and host evolution in response to a highly virulent pathogen, we attempted to determine genetic markers associated with plague resistance in this species. {T}o this purpose, we combined a population genomics approach and an association study, both performed on 249 {AFLP} markers, in {M}alagasy {R}. rattus. {S}imulated distributions of genetic differentiation were compared to observed data in four independent pairs, each consisting of one population from the plague focus and one from the plague-free zone. {W}e found 22 loci (9% of 249) with higher differentiation in at least two independent population pairs or with combining {P}-values over the four pairs significant. {A}mong the 22 outlier loci, 16 presented significant association with plague zone (plague focus vs. plague-free zone). {P}opulation genetic structure inferred from outlier loci was structured by plague zone, whereas the neutral loci dataset revealed structure by geography (eastern vs. western populations). {A} phenotype association study revealed that two of the 22 loci were significantly associated with differentiation between dying and surviving rats following experimental plague challenge. {T}he 22 outlier loci identified in this study may undergo plague selective pressure either directly or more probably indirectly due to hitchhiking with selected loci.},
  keywords = {adaptation genetics ; association study ; disease resistance ; pathogen-mediated selection ; population genomics ; {Y}ersinia pestis},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {20},
  numero = {5},
  pages = {1026--1038},
  ISSN = {0962-1083},
  year = {2011},
  DOI = {10.1111/j.1365-294{X}.2010.04633.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053133},
}