da Silva A. J. M., Netto C. D., Pacienza-Lima W., Torres-Santos E. C., Rossi-Bergmann B., Maurel Séverine, Valentin A., Costa P. R. R. (2009). Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives. Journal of the Brazilian Chemical Society, 20 (1), p. 176-U222. ISSN 0103-5053.
Titre du document
Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
da Silva A. J. M., Netto C. D., Pacienza-Lima W., Torres-Santos E. C., Rossi-Bergmann B., Maurel Séverine, Valentin A., Costa P. R. R.
Source
Journal of the Brazilian Chemical Society, 2009,
20 (1), p. 176-U222 ISSN 0103-5053
Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA).
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
