@article{fdi:010052857,
  title = {{L}ow linkage disequilibrium in wild {A}nopheles gambiae s.l. populations},
  author = {{H}arris, {C}. and {R}ousset, {F}. and {M}orlais, {I}sabelle and {F}ontenille, {D}idier and {C}ohuet, {A}nna},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n the malaria vector {A}nopheles gambiae, understanding diversity in natural populations and genetic components of important phenotypes such as resistance to malaria infection is crucial for developing new malaria transmission blocking strategies. {T}he design and interpretation of many studies here depends critically on {L}inkage disequilibrium ({LD}). {F}or example in association studies, {LD} determines the density of {S}ingle {N}ucleotide {P}olymorphisms ({SNP}s) to be genotyped to represent the majority of the genomic information. {H}ere, we aim to determine {LD} in wild {A}n. gambiae s.l. populations in 4 genes potentially involved in mosquito immune responses against pathogens ({G}ambicin, {NOS}, {REL}2 and {FBN}9) using previously published and newly generated sequences. {R}esults: {T}he level of {LD} between {SNP} pairs in cloned sequences of each gene was determined for 7 species (or incipient species) of the {A}n. gambiae complex. {I}n all tested genes and species, {LD} between {SNP}s was low: even at short distances (< 200 bp), most {SNP} pairs gave an r(2) < 0.3. {M}ean r(2) ranged from 0.073 to 0.766. {I}n most genes and species {LD} decayed very rapidly with increasing inter-marker distance. {C}onclusions: {T}hese results are of great interest for the development of large scale polymorphism studies, as {LD} generally falls below any useful limit. {I}t indicates that very fine scale {SNP} detection will be required to give an overall view of genome-wide polymorphism. {P}erhaps a more feasible approach to genome wide association studies is to use targeted approaches using candidate gene selection to detect association to phenotypes of interest.},
  keywords = {},
  booktitle = {},
  journal = {{BMC} {G}enetics},
  volume = {11},
  numero = {1},
  pages = {81},
  ISSN = {1471-2156},
  year = {2010},
  DOI = {10.1186/1471-2156-11-81},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052857},
}