%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A De Marino, S.
%A Sepe, V.
%A D'Auria, M. V.
%A Bifulco, G.
%A Renga, B.
%A Petek, Sylvain
%A Fiorucci, S.
%A Zampella, A.
%T Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei
%D 2011
%L fdi:010052514
%G ENG
%J Organic and Biomolecular Chemistry
%@ 1477-0520
%M ISI:000291654800026
%N 13
%P 4856-4862
%R 10.1039/c1ob05378g
%U https://www.documentation.ird.fr/hor/fdi:010052514
%> https://www.documentation.ird.fr/intranet/publi/depot/2011-11-21/010052514.pdf
%V 9
%W Horizon (IRD)
%X Malaitasterol A, an unprecedented bis-secosterol, was isolated from a Solomon collection of Theonella swinhoei. The structure was elucidated on the basis of a combination of comprehensive 1D and 2D NMR analysis, high-resolution mass spectrometry and DFT C-13 chemical shift calculations. The biological characterization of malaitasterol A provided evidence that this compound is a potent agonist of pregnane-X-receptor and its putative binding mode to PXR has been obtained through docking calculations.
%$ 035