@article{fdi:010052514,
  title = {{T}owards new ligands of nuclear receptors. {D}iscovery of malaitasterol {A}, an unique bis-secosterol from marine sponge {T}heonella swinhoei},
  author = {{D}e {M}arino, {S}. and {S}epe, {V}. and {D}'{A}uria, {M}. {V}. and {B}ifulco, {G}. and {R}enga, {B}. and {P}etek, {S}ylvain and {F}iorucci, {S}. and {Z}ampella, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaitasterol {A}, an unprecedented bis-secosterol, was isolated from a {S}olomon collection of {T}heonella swinhoei. {T}he structure was elucidated on the basis of a combination of comprehensive 1{D} and 2{D} {NMR} analysis, high-resolution mass spectrometry and {DFT} {C}-13 chemical shift calculations. {T}he biological characterization of malaitasterol {A} provided evidence that this compound is a potent agonist of pregnane-{X}-receptor and its putative binding mode to {PXR} has been obtained through docking calculations.},
  keywords = {},
  booktitle = {},
  journal = {{O}rganic and {B}iomolecular {C}hemistry},
  volume = {9},
  numero = {13},
  pages = {4856--4862},
  ISSN = {1477-0520},
  year = {2011},
  DOI = {10.1039/c1ob05378g},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052514},
}