%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Longeon, A.
%A Copp, B. R.
%A Roué, M.
%A Dubois, J.
%A Valentin, A.
%A Petek, Sylvain
%A Debitus, Cécile
%A Bourguet-Kondracki, M. L.
%T New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia
%D 2010
%L fdi:010049723
%G ENG
%J Bioorganic and Medicinal Chemistry
%@ 0968-0896
%K Xestospongia ; Marine sponge ; Marine natural product ; Halenaquinone ; PLA(2) inhibitor ; FTase inhibitor ; Antiplasmodial compound
%M ISI:000280664100025
%N 16
%P 6006-6011
%R 10.1016/j.bmc.2010.06.066
%U https://www.documentation.ird.fr/hor/fdi:010049723
%> https://www.documentation.ird.fr/intranet/publi/2010/09/010049723.pdf
%V 18
%W Horizon (IRD)
%X Bioassay-directed fractionation of South Pacific marine sponges of the genus Xestospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol C methylacetal 7 and orhalquinone 8. Chemical characterization of these two new compounds was achieved by extensive 1D and 2D NMR spectroscopic studies. Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. Orhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with IC50 value of 0.40 mu M and was a moderate growth inhibitor of Plasmodium falciparum.
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