@article{fdi:010049723,
  title = {{N}ew bioactive halenaquinone derivatives from {S}outh {P}acific marine sponges of the genus {X}estospongia},
  author = {{L}ongeon, {A}. and {C}opp, {B}. {R}. and {R}ou{\'e}, {M}. and {D}ubois, {J}. and {V}alentin, {A}. and {P}etek, {S}ylvain and {D}ebitus, {C}{\'e}cile and {B}ourguet-{K}ondracki, {M}. {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ioassay-directed fractionation of {S}outh {P}acific marine sponges of the genus {X}estospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol {C} methylacetal 7 and orhalquinone 8. {C}hemical characterization of these two new compounds was achieved by extensive 1{D} and 2{D} {NMR} spectroscopic studies. {E}valuation of anti-phospholipase {A}(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. {O}rhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with {IC}50 value of 0.40 mu {M} and was a moderate growth inhibitor of {P}lasmodium falciparum.},
  keywords = {{X}estospongia ; {M}arine sponge ; {M}arine natural product ; {H}alenaquinone ; {PLA}(2) inhibitor ; {FT}ase inhibitor ; {A}ntiplasmodial compound},
  booktitle = {},
  journal = {{B}ioorganic and {M}edicinal {C}hemistry},
  volume = {18},
  numero = {16},
  pages = {6006--6011},
  ISSN = {0968-0896},
  year = {2010},
  DOI = {10.1016/j.bmc.2010.06.066},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049723},
}