%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Akbaraly, T. N.
%A Arnaud, J.
%A Rayman, M. P.
%A Hininger-Favier, I.
%A Roussel, A. M.
%A Berr, C.
%A Fontbonne, Annick
%T Plasma selenium and risk of dysglycemia in an elderly French population : results from the prospective Epidemiology of Vascular Ageing Study
%D 2010
%L fdi:010049441
%G ENG
%J Nutrition and Metabolism
%@ 1743-7075
%M ISI:000276430800001
%P 21
%R 10.1186/1743-7075-7-21
%U https://www.documentation.ird.fr/hor/fdi:010049441
%> https://www.documentation.ird.fr/intranet/publi/2010/04/010049441.pdf
%V 7
%W Horizon (IRD)
%X Background: A preventive role of selenium on the risk of diabetes has been reported and ascribed to the "insulin-like" activity of selenium and the antioxidant properties of the selenoenzymes. By contrast, data from cross-sectional studies and clinical trials have suggested an adverse effect of high selenium status and selenium supplementation on type-2 diabetes risk. Given these controversial results, we investigated prospectively the relationship between baseline plasma selenium concentration and occurrence of dysglycemia (impaired fasting glucose or type 2 diabetes) in an elderly French cohort. Methods: The Epidemiology of Vascular Ageing (EVA) study (n = 1389, 59-71 years) is a 9-year longitudinal study in which, fasting plasma glucose was measured at baseline, 2, 4 and 9 years. Analyses were performed on 1162 participants with complete data. Results: At baseline plasma selenium mean levels were 1.08 (0.21) mu mol/l in men and 1.10 (0.20) mu mol/l in women. During the 9-year follow-up, 127 cases of dysglycemia occurred. A significant interaction was found between plasma selenium and sex. Risk of dysglycemia was significantly lower in men with plasma selenium in the highest tertile (T3: 1.19-1.97) compared to those in the lowest tertile (T1: 0.18-1.00) [HR = 0.48 (0.25-0.92)], but no significant relationship was observed in women. After controlling for socio-demographic factors, lifestyle factors, cardiovascular diseases, body mass index, hypertension and lipid profile, plasma selenium remained marginally significantly associated with occurrence of dysglycemia in men [T3 vs. T1, HR = 0.50 (0.24-1.04)] and unrelated in women. Conclusions: This prospective study suggests a sex-specific protective effect of higher selenium status at baseline on later occurrence of dysglycemia.
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