@article{fdi:010049441,
  title = {{P}lasma selenium and risk of dysglycemia in an elderly {F}rench population : results from the prospective {E}pidemiology of {V}ascular {A}geing {S}tudy},
  author = {{A}kbaraly, {T}. {N}. and {A}rnaud, {J}. and {R}ayman, {M}. {P}. and {H}ininger-{F}avier, {I}. and {R}oussel, {A}. {M}. and {B}err, {C}. and {F}ontbonne, {A}nnick},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A} preventive role of selenium on the risk of diabetes has been reported and ascribed to the "insulin-like" activity of selenium and the antioxidant properties of the selenoenzymes. {B}y contrast, data from cross-sectional studies and clinical trials have suggested an adverse effect of high selenium status and selenium supplementation on type-2 diabetes risk. {G}iven these controversial results, we investigated prospectively the relationship between baseline plasma selenium concentration and occurrence of dysglycemia (impaired fasting glucose or type 2 diabetes) in an elderly {F}rench cohort. {M}ethods: {T}he {E}pidemiology of {V}ascular {A}geing ({EVA}) study (n = 1389, 59-71 years) is a 9-year longitudinal study in which, fasting plasma glucose was measured at baseline, 2, 4 and 9 years. {A}nalyses were performed on 1162 participants with complete data. {R}esults: {A}t baseline plasma selenium mean levels were 1.08 (0.21) mu mol/l in men and 1.10 (0.20) mu mol/l in women. {D}uring the 9-year follow-up, 127 cases of dysglycemia occurred. {A} significant interaction was found between plasma selenium and sex. {R}isk of dysglycemia was significantly lower in men with plasma selenium in the highest tertile ({T}3: 1.19-1.97) compared to those in the lowest tertile ({T}1: 0.18-1.00) [{HR} = 0.48 (0.25-0.92)], but no significant relationship was observed in women. {A}fter controlling for socio-demographic factors, lifestyle factors, cardiovascular diseases, body mass index, hypertension and lipid profile, plasma selenium remained marginally significantly associated with occurrence of dysglycemia in men [{T}3 vs. {T}1, {HR} = 0.50 (0.24-1.04)] and unrelated in women. {C}onclusions: {T}his prospective study suggests a sex-specific protective effect of higher selenium status at baseline on later occurrence of dysglycemia.},
  keywords = {},
  booktitle = {},
  journal = {{N}utrition and {M}etabolism},
  volume = {7},
  numero = {},
  pages = {21},
  ISSN = {1743-7075},
  year = {2010},
  DOI = {10.1186/1743-7075-7-21},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049441},
}