Magid A. A. auteur aut IRD Bobichon H. auteur aut IRD Borie N. auteur aut IRD Lalun N. auteur aut IRD Long C. auteur aut IRD Moretti Christian auteur aut IRD Lavaud C. auteur aut IRD text journalArticle eng text/pdf born digital access Phytochemical investigation of the MeOH extract of the stem bark of Antonia ovata led to the isolation of four triterpenoid saponins, along with eleven known Compounds Their structures were established by extensive 1D and 2D NMR, as well as HR-MS analysis and acid hydrolysis All isolated saponins contained the same tetrasaccharide chain O-beta-D-xylopyranosyl-(1 -> 2)-O-beta-D-glucopyranosyl-(1 -> 3)-O-[beta-D-glucopyranosyl-(1 -> 2)]-beta-D-glucuropyranoside linked to C-3 of esterified derivatives of R-1-barrigenol. A(1)-barrigenol, barringtogenol C, or camelliagenin Biological evaluation of the Compounds against KB cell line revealed a potent cytotoxic activity with IC50 Values ranging from 3 1 to 6 6 mu M. The known compounds were found to be inactive at 10 mu g/ml concentration. specialized Antonia ovata Loganiaceae Triterpenoid saponins R-1-barrigenol A(1)-barrigenol Barringtogenol C Camelliagenin Cytotoxic activity 076 71 4 429-434 2010 0031-9422 https://www.documentation.ird.fr/hor/fdi:010049393 10.1016/j.phytochem.2009.11.007 0031-9422 [F B010049393] https://www.documentation.ird.fr/hor/fdi:010049393 https://www.documentation.ird.fr/intranet/publi/2010/04/010049393.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2010-05-03 2017-08-23 fdi:010049393 fre