@article{fdi:010046218,
  title = {{A}bility of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in {RAW} 264.7 macrophages},
  author = {{K}umar {R}oin{\'e}, {S}hilpa and {M}atsui, {M}ariko and {R}eybier, {K}. and {D}arius, {H}. {T}. and {C}hinain, {M}. and {P}auillac, {S}. and {L}aurent, {D}ominique},
  editor = {},
  language = {{ENG}},
  abstract = {{A}im of the study: {C}iguatera fish poisoning ({CFP}) is an intertropical ichthyosarcotoxism that manifests in complex assortment of symptoms in humans. {C}iguatoxins ({CTX}s), issued from {G}ambierdicus spp., are causative agents of this intoxication. {W}e have recently demonstrated that a {P}acific {CTX} ({P}-{CTX}-1 {B}) strongly modulated i{NOS} expression, leading to overproduction of nitric oxide ({NO}) in {RAW} 264.7 murine macrophage cells. {NO} produced in large amounts is involved in a wide range of pathophysiological processes. {M}any traditional remedies are commonly used in the {P}acific against {CFP}. {I}n this context, bioassay-guided screening was carried out to study {NO} inhibiting capacity of 28 selected plant extracts. {M}aterials and methods: {W}e prepared aqueous extracts of plants used in {N}ew {C}aledonia in the treatment of {CFP} and screened their {NO} inhibitory activity in lipopolysaccharide ({LPS})-activated {RAW} 264.7 macrophages. {R}esults: {A}mong 28 plants tested, {E}uphorbia hirta ({E}uphorbiaceae), {S}yzygium malaccense ({M}yrtaceae), {S}chinus terebenthifolius ({A}nacardiaceae), {P}unica granatum ({P}unicaceae), {C}erbera manghas ({A}pocynaceae), {V}itex trifolia ({L}abiateae) and {X}imenia americana ({O}lacaceae) showed inhibitory activity, validating their use as traditional remedies in {CFP}, and the potential for use in the treatment of conditions accompanied by {NO} overproduction. {C}onclusion: {T}hese plants are promising candidates for further screening of their active compounds through activity-guided fractionation.},
  keywords = {{N}itric oxide ; {F}olk remedies ; {C}iguatera fish poisoning ; {L}ipopolysaccharide ; {RAW} 264.7 macrophage},
  booktitle = {},
  journal = {{J}ournal of {E}thnopharmacology},
  volume = {123},
  numero = {3},
  pages = {369--377},
  ISSN = {0378-8741},
  year = {2009},
  DOI = {10.1016/j.jep.2009.03.039},
  URL = {https://www.documentation.ird.fr/hor/fdi:010046218},
}