Kumar Roiné Shilpa, Matsui Mariko, Reybier K., Darius H. T., Chinain M., Pauillac S., Laurent Dominique. (2009). Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages. Journal of Ethnopharmacology, 123 (3), p. 369-377. ISSN 0378-8741.
Titre du document
Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages
Kumar Roiné Shilpa, Matsui Mariko, Reybier K., Darius H. T., Chinain M., Pauillac S., Laurent Dominique
Source
Journal of Ethnopharmacology, 2009,
123 (3), p. 369-377 ISSN 0378-8741
Aim of the study: Ciguatera fish poisoning (CFP) is an intertropical ichthyosarcotoxism that manifests in complex assortment of symptoms in humans. Ciguatoxins (CTXs), issued from Gambierdicus spp., are causative agents of this intoxication. We have recently demonstrated that a Pacific CTX (P-CTX-1 B) strongly modulated iNOS expression, leading to overproduction of nitric oxide (NO) in RAW 264.7 murine macrophage cells. NO produced in large amounts is involved in a wide range of pathophysiological processes. Many traditional remedies are commonly used in the Pacific against CFP. In this context, bioassay-guided screening was carried out to study NO inhibiting capacity of 28 selected plant extracts. Materials and methods: We prepared aqueous extracts of plants used in New Caledonia in the treatment of CFP and screened their NO inhibitory activity in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Results: Among 28 plants tested, Euphorbia hirta (Euphorbiaceae), Syzygium malaccense (Myrtaceae), Schinus terebenthifolius (Anacardiaceae), Punica granatum (Punicaceae), Cerbera manghas (Apocynaceae), Vitex trifolia (Labiateae) and Ximenia americana (Olacaceae) showed inhibitory activity, validating their use as traditional remedies in CFP, and the potential for use in the treatment of conditions accompanied by NO overproduction. Conclusion: These plants are promising candidates for further screening of their active compounds through activity-guided fractionation.
Plan de classement
Santé : généralités [050]
;
Sciences du monde végétal [076]
