The genetic structure and history of Africans and African Americans

2009

Article référencé dans le Web of Science WOS:000266246700033

Tishkoff S.A., Reed F.A., Friedlaender F.R., Ehret C., Ranciaro A., Froment Alain, Hirbo J.B., Awomoyi A.A., Bodo J.M., Doumbo O., Ibrahim M., Juma A.T., Kotze M.J., Lema G., Moore J.H., Mortensen H., Nyambo T.B., Omar S.A., Powell K., Pretorius G.S., Smith M.W., Thera M.A., Wambebe C., Weber J.L., Williams S.M.

Science, 2009, 324 (5930), p. 1035-1044 ISSN 0036-8075

Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (similar to 71%), European (similar to 13%), and other African (similar to 8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies.

Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Société, développement social [106]

AFRIQUE SUBSAHARIENNE ; AMERIQUE DU NORD

Fonds IRD [F B010046097]

fdi:010046097