Roumy V., Fabre N., Portet B., Bourdy Geneviève, Acebey L., Vigor C., Valentin A., Moulis C. (2009). Four anti-protozoal and anti-bacterial compounds from Tapirira guianensis. Phytochemistry, 70 (2), p. 305-311. ISSN 0031-9422.
Titre du document
Four anti-protozoal and anti-bacterial compounds from Tapirira guianensis
Année de publication
2009
Auteurs
Roumy V., Fabre N., Portet B., Bourdy Geneviève, Acebey L., Vigor C., Valentin A., Moulis C.
Source
Phytochemistry, 2009,
70 (2), p. 305-311 ISSN 0031-9422
Tapirira guianensis is a common tree used in traditional medicine in French Guiana against several infectious diseases (malaria, leishmaniasis, bacteria, etc.). The bioassay-guided purification of CH2Cl2 bark extract led to the isolation of four cyclic alkyl polyol derivatives: 4,6,2'-trihydroxy-6-[10'(Z)-heptadecenyl]-1-cyclohexen-2-one (1a), 1,4,6-trihydroxy-1,2'-epoxy-6-[10'(Z)-heptadecenyl]-2-cyclohexene (1b), 1,4,5,2'-tetrahydroxy-1-[10'(Z)-heptadecenyl]-2-cyclohexene (2), and 1,3,4,6-tetrahydroxy-1,2'-epoxy-6-[10'(Z)-heptadecenyl]-cyclohexane (3). The structures were established on the basis of ID and 2D NMR analyses. The anti-leishmanial, anti-plasmodial, anti-bacterial (on Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli), and anti-fungal (on Candida albicans) activities of the extracts and of these original compounds were evaluated. Two showed medicinal interest supporting the traditional uses of the plant. The structures were established through spectral analyses of the isolates and their derivatives.
Plan de classement
Sciences du monde végétal [076]
Localisation
Fonds IRD [F B010044342]
Identifiant IRD
fdi:010044342
