Botelho-Nevers E., Rolain J. M., Espinosa L., Raoult Didier. (2008). Statins limit Rickettsia conorii infection in cells. International Journal of Antimicrobial Agents, 32 (4), p. 344-348. ISSN 0924-8579.
Titre du document
Statins limit Rickettsia conorii infection in cells
Botelho-Nevers E., Rolain J. M., Espinosa L., Raoult Didier
Source
International Journal of Antimicrobial Agents, 2008,
32 (4), p. 344-348 ISSN 0924-8579
Recent data suggest that statins may have a beneficial effect during sepsis. In this study, we tested the effect of lovastatin and pravastatin on the cellular culture of Rickettsia conorii using a quantitative plaque assay model associated with an original image analysis algorithm. Statins added at the time of infection did not modify plaque formation, whereas pre-incubation with statins for 48 h resulted in a significant 30-68% plaque reduction, depending on the tested compounds and doses. These preliminary findings raise the hypothesis that statins may prevent or moderate rickettsial disease in exposed people.
