@article{fdi:010042640, title = {{C}omparison of {A}nopheles gambiae and {C}ulex pipiensacetycholinesterase 1 biochemical properties}, author = {{A}lout, {H}. and {D}jogb{\'e}nou, {L}uc and {B}erticat, {C}. and {C}handre, {F}abrice and {W}eill, {M}.}, editor = {}, language = {{ENG}}, abstract = {{S}election of insensitive acetycholinesterase 1 ({AC}h{E}1) has occurred in several mosquito species controlled with carbarnate ({CX}) and organophosphate ({OP}) insecticides. {I}n case of pyrethroid resistance, these insecticides represent an alternative for disease vector control program. {T}heir heavy use in agriculture has selected resistant populations of {A}nopheles gambiae in {W}est {A}frica. {T}he evolution of resistance has to be studied to prevent, or at least slow down, the spread of resistant mosquito in wild populations. {A}n. gambiae shares the same resistance mechanism to {CX} and {OP} insecticides as {C}ulex pipiens, which was attributed to the {G}119{S} substitution in the {AC}h{E}1 enzyme. {B}y comparing resistant {AC}h{E}-1 from both species, we show here that similar resistance levels are obtained toward 10 insecticides of both classes. {M}oreover, similar {AC}h{E}1 activity levels are recorded between either susceptible or resistant mosquitoes of both species. {E}nzymes belonging to both species seem thus to share identical properties. {C}onsequently, we hypothesize that fitness cost associated with {AC}h{E}1 insensitivity in {C}. pipiens mosquitoes should be similar in {A}n. gambiae and thus be used in strategies to control resistant populations where malaria is prevalent.}, keywords = {{A}nopheles gambiae ; {C}ulex pipiens ; {I}nsensitive ache ; {R}esistance management}, booktitle = {}, journal = {{C}omparative {B}iochemistry and {P}hysiology {P}art {B} : {B}iochemistry and {M}olecular {B}iology}, volume = {150}, numero = {3}, pages = {271--277}, ISSN = {1096-4959}, year = {2008}, DOI = {10.1016/j.cbpb.2008.03.008}, URL = {https://www.documentation.ird.fr/hor/fdi:010042640}, }