@article{fdi:010040764,
  title = {{D}evelopment of a {SPE}/{HPLC}/{DAD} method for the determination of antileishmanial 2-substituted quinolines and metabolites in rat plasma},
  author = {{D}esrivot, {J}. and {M}oussa, {F}. and {C}hampy, {P}. and {F}ournet, {A}lain and {F}igad{\`e}re, {B}. and {H}errenknecht, {C}.},
  abstract = {{A} {SPE}/{HPLC}/{DAD} method was developed for the in vivo monitoring of three new antileishmanial 2-substituted quinolines under study in our laboratory for the development of an oral treatment. {T}hree phase {I} metabolites were included in this work for the optimization of the method. {T}rifunctional t{C}(18) cartridges (resulting from the reaction of trifunctional silanes with silica surface) were selected among four sorbents tested. {T}wo linear gradients were developed to ensure resolution of metabolites. {R}ecovery of quinolines from rat plasma was comprised between 80.6 and 88.2%. {I}n a drug development perspective, apparent p{K},, lipophilicity and solubility were determined, as well as the extent of plasma protein or albumin binding.},
  keywords = {leishmaniasis ; solid phase extraction ; 2 substituted quinoline ; protein binding ; lipophilicity ; solubility},
  journal = {{J}ournal of {C}hromatography {B} {A}nalytical {T}echnologies in the {B}iomedical and {L}ife {S}ciences},
  volume = {854},
  numero = {1-2},
  pages = {230--238},
  ISSN = {1570-0232},
  year = {2007},
  DOI = {10.1016/j.jchromb.2007.04.029},
  URL = {http://www.documentation.ird.fr/hor/fdi:010040764},
}