@article{fdi:010040646,
  title = {{M}alaria {P}lasmodium agent induces alteration in the head proteome of their {A}nopheles mosquito host},
  author = {{L}ef{\`e}vre, {T}hierry and {T}homas, {F}. and {S}chwartz, {A}. and {L}evashina, {E}. and {B}landin, {S}. and {B}rizard, {J}ean-{P}aul and {L}e {B}ourligu, {L}. and {D}emettre, {E}. and {R}enaud, {F}ran{\c{c}}ois and {B}iron, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{D}espite increasing evidence of behavioural manipulation of their vectors by pathogens, the underlying mechanisms causing infected vectors to act in ways that benefit pathogen transmission remain enigmatic in most cases. {H}ere, 2-{D} {DIGE} coupled with {MS} were employed to analyse and compare the head proteome of mosquitoes ({A}nopheles gambiae sensu stricto ({G}iles)) infected with the malarial parasite ({P}lasmodium berghei) with that of uninfected mosquitoes. {T}his approach detected altered levels of 12 protein spots in the head of mosquitoes infected with sporozoites. {T}hese proteins were subsequently identified using {MS} and functionally classified as belonging to metabolic, synaptic, molecular chaperone, signalling, and cytoskeletal groups. {O}ur results indicate an altered energy metabolism in the head of sporozoite-infected mosquitoes. {S}ome of the up-/down-regulated proteins identified, such as synapse-associated protein, 14-3-3 protein and calmodulin, have previously been shown to play critical roles in the {CNS} of both invertebrates and vertebrates. {F}urthermore, a heat shock response ({HSP} 20) and a variation of cytoarchitecture (tropomyosins) have been shown. {D}iscovery of these proteins sheds light on potential molecular mechanisms that underlie behavioural modifications and offers new insights into the study of intimate interactions between {P}lasmodium and its {A}nopheles vector.},
  keywords = {2 {DE} ; host parasite systems ; malaria ; {MS} ; mosquitoes},
  booktitle = {},
  journal = {{P}roteomics},
  volume = {7},
  numero = {11},
  pages = {1908--1915},
  ISSN = {1615-9853},
  year = {2007},
  DOI = {10.1002/pmic.200601021},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040646},
}