@article{fdi:010040639,
  title = {{A}n insight into immunogenic salivary proteins of {A}nopheles gambiae in {A}frican children - art. no. 75},
  author = {{C}orn{\'e}lie, {S}ylvie and {R}emou{\'e}, {F}ranck and {D}oucour{\'e}, {S}ouleymane and {ND}iaye, {T}of{\`e}ne and {S}auvage, {F}. {X}. and {B}oulanger, {D}enis and {S}imondon, {F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {D}uring blood feeding, the mosquito injects saliva into the vertebrate host. {T}his saliva contains bioactive components which may play a role in pathogen transmission and in host-vector relationships by inducing an immune response in the vertebrate host. {T}he evaluation of human immune responses to arthropod bites might also represent a research direction for assessing individual exposure to the bite of a malaria vector. {M}ethods: {T}he present study examined the antibody ( {A}b) {I}g{G} response during the season of exposure to {A}nopheles gambiae bites in young children living in a malaria endemic area. {I}mmunoblots were performed with {A}n. gambiae saliva to detect anti-saliva {A}b bands and the evolution of immunogenic bands at the peak of, and following, the transmission period. {R}esults: {T}he results showed that anti-{A}nopheles {A}b was directed against a limited number of salivary proteins ( 175, 115, 72 and 30 k{D}a bands). {S}pecific {I}g{G} responses to mosquito salivary proteins were variable among exposed individuals; nevertheless, two major bands ( 175 and 72 k{D}a) were observed in all immune-responder children. {A}nalysis of the intensity of immunogenic bands revealed that {I}g{G} levels against the 175 k{D}a band were significantly higher during the peak period compared to the end period malaria transmission. {C}onclusion: {T}his preliminary work supports the potential of using anti-saliva immune responses as a measure of exposure to {A}nopheles bites. {T}he use of immunoblots coupled with evaluation of band intensity could be an adequate tool for distinguishing immunogenic salivary proteins as candidate markers of bite exposure. {F}urthermore, this study may open the way to design new epidemiological tools for evaluating the risk of malaria exposure.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {6},
  numero = {},
  pages = {{NIL}_1--{NIL}_7},
  ISSN = {1475-2875},
  year = {2007},
  DOI = {10.1186/1475-2875-6-75},
  URL = {https://www.documentation.ird.fr/hor/fdi:010040639},
}