CastilloD.auteurautArevaloJ.auteurautHerreraF.auteurautRuizC.auteurautRojasR.auteurautRengifoE.auteurautVaisbergA.auteurautLockO.auteurautLemesreJean-LoupauteurautIRDGornitzkaH.auteurautSauvainMichelauteurautIRDtextjournalArticletext/pdfborn digitalaccessExtracts of seven medicinal plants used specifically against cutaneous leishmaniasis in the Madre de Dios region of Peru were evaluated in vitro against promastigote and axenic amastigote forms of Leishmania amazonensis. One of them showed interesting leishmanicidal activities (IC50 = 5 mu g/ml in amastigotes). Bio-guided isolation of the stem bark's ethanol extract of Himatanthus sucuuba (Spruce ex Mull. Arg.) Woodson (Apocynaceae) afforded the spirolactone iridoids isoplumericin and plumericin. The latter showed a reduction of macrophage infection similar to that of the reference drug Amphotericin B (IC50 = 0.9 and 1 mu M, respectively). These findings validate the traditional use of Himatanthus sucuuba in the treatment of cutaneous leishmaniasis (Uta) in Peru.specializedLeishmania amazonensisPeruHimatanthus sucitubaplumericinethnomedicineaxenic amastigotes052 076 112241041420070378-8741http://www.documentation.ird.fr/hor/fdi:01004063810.1016/j.jep.2007.03.025IRD BondyF B010040638http://www.documentation.ird.fr/hor/fdi:010040638http://www.documentation.ird.fr/intranet/publi/2007/08/010040638.pdfAccès réservé (Intranet de l'IRD)IRD - Base Horizon / Pleins textes2007-09-042010-08-04fdi:010040638fre